Lead Compound and Developmental Drug Candidate Evaluation Services Core Facilities
IBPR offers platform technology services of pharmacology, pharmacokinetics, exploratory toxicology, metabolite target analysis and physicochemical characterization for the discovery of small molecule drugs.
Customized services needed for lead compound and drug candidate selections are available upon inquiry.
Technology Services：
| 1、Efficacy Evaluation In Disease Animal Models |
| Service number |
Technology and Service List |
| BP-AM-001 |
Subcutaneously xenografted tumor growth models-mouse |
| BP-AM-002 |
Orthotropically xenografted tumor growth models-mouse |
| BP-AM-003 |
STZ-induced diabetic model-rat |
| BP-AM-004 |
Diet-induced obese mouse model |
| BP-AM-005 |
Oral glucose tolerance test-mouse |
| BP-AM-006 |
Oral glucose tolerance test-rat |
| 2、Pharmacokinetics and Metabolite Target Analysis |
| Service number |
Technology and Service List |
| BP-PK-001 |
Bioanalytical method development |
| BP-PK-002 |
Protein binding determination |
| BP-PK-003 |
Microsomal stability evaluation |
| BP-PK-004 |
CYP inhibition assay |
| BP-PK-005 |
PK/bioavailability in mice |
| BP-PK-006 |
PK/bioavailability in rats |
| BP-PK-007 |
PK/bioavailability in minipigs |
| BP-PK-008 |
Metabolite identification |
| 3、Physicochemical characterization and formulation evaluation |
| Service number |
Technology and Service List |
| BP-PD-001 |
X-ray Powder Diffraction (XRPD) |
| BP-PD-002 |
Raman Spectroscopy |
| BP-PD-003 |
Dynamic Vapor Sorption (DVS) |
| BP-PD-004 |
Water content (Karl Fischer coulometric titrator) |
| BP-PD-005 |
Differential scanning calorimetry (DSC) |
| BP-PD-006 |
Thermogravimetric analyzer (TGA) |
| BP-PD-007 |
Capsule filling and sealing systems |
| BP-PD-008 |
Dissolution tests |
| BP-PD-009 |
Micro-Osmometer |
| BP-PD-0010 |
Air jet mill micronizer |
| BP-PD-0011 |
Polarized light microscopy(Leica DM2500 P) |
| BP-PD-0012 |
Solubility |
| 4、Chemical Characterization |
| Service number |
Technology and Service List |
| BP-CH-001 |
Nuclear Magnetic Resonance Spectroscopy (NMR) |
| BP-CH-002 |
Liquid Chromatography / Mass Spectroscopy (LC/MS) |
| BP-CH-003 |
Purity Check (Purity) |
| BP-CH-004 |
Analytical method development |
| 5、In Vitro Toxicity |
| Service number |
Technology and Service List |
| BP-IVT-001 |
MTS assay |
| BP-IVT-002 |
In vitro hemolysis assays ( mouse, rat, rabbit, dog, pig, and minipigs) |
| 6、Human coronavirus test |
| Service number |
Technology and Service List |
| BP-HCoV-001 |
In vitro FRET based SARS-CoV-2 3CL protease assay |
| 7、Protein activity screening platforms List |
| Service number |
Technology and Service List |
| BP-CE-E |
Enzyme |
| BP-CE-K |
Kinases |
| BP-CE-V |
Viruses |
| BP-CE-T |
Transcription |
Service charges may be subject to the condition of the studies requested. Please feel free to contact us via bp-service@nhri.edu.tw for the cases of your interest.
IBPR-Service Request Form Download: WORD PDF
Please complete the IBPR-Service Request Form and email bp-service@nhri.edu.tw to us.
If you are interested in our services of compound synthesis, please refer to https://ibpr.nhri.edu.tw/en/index.php/vmic/
