Tsung Jen Liao

CW Tung 2Tsung Jen Liao, Ph.D.
Assistant Investigator
Institute of Biotechnology and Pharmaceutical Research
Email: tjliao@nhri.edu.tw

 

EDUCATION

  • Ph.D. in Biophysics, University of Maryland, College Park, USA (2014-2021)
  • M.S. in Applied Physics, National Taiwan University, Taiwan (2010-2012)
  • B.S. in Physics, National Tsing-Hua University, Taiwan (2005-2009)

RESEARCH EXPERIENCES

  • Assistant Investigator, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan (2026-present)
  • Postdoctoral IRTA Fellow, National Center for Advancing Translational Sciences, National Institute of Health, USA (2022-2025)
  • Postdoctoral ORISE Fellow, National Center for Toxicological Research, U.S. Food and Drug Administration, USA (2020-2022)
  • Visiting Graduate Fellow, National Cancer Institute, National Institute of Health, USA (2015-2020)

RESEARCH INTERESTS

Biophysics, Biochemistry, Bioinformatics

HONORS & AWARDS

  • Translational Science Interagency Fellowship, NCATS, NIH (2022-2025)
  • Outstanding Graduate Assistant Award, UMD (2018)
  • Outstanding Poster in Structural Biology and Chemistry, Fort Detrick (2018)
  • Cancer Research Training Award Fellowship, NCI, NIH (2017-2020)
  • Studying abroad Scholarship, Taiwan (2017-2019)
  • Dean’s Fellowship, UMD (2014, 2017)

PUBLICATIONS

  1. TJ. Liao, M. Xia, D. Tao, Y. Qu, B. Ning, J. Rule, W. Lee, R. Huang, J. Rakela, M. Chen: Identification of genetic risk factors associated with herbal and dietary supplement–induced acute liver failure using whole exome sequencing analysis, Gastro Hep Advance, 2025, 100716
  2. TJ. Liao, M. Xia, P. Hayashi, B. Pan, G. Aithal, M. Lucena, R. Andrade, J. Rule, W. Lee, J. Rakela, R. Huang, M. Chen: Genetic variants of GBP4: reduced risks for drug-induced acute liver failure, Liver International, 2025, 45 (2), e70011
  3. TJ. Liao, L. Crosby, K. Cross, G. Halford, M. Chen, R. Elespuru: Medical device report analyses from MAUDE: Device and patient outcomes, adverse events, and sex-based differential effects. Regulatory Toxicology and Pharmacology, 2024, 149, 105591
  4. A. Olubamiwa, TJ. Liao, J. Zhao, P. Dehanne, C. Noban, Y. Angin, O. Barberan, M. Chen: Drug interaction with UDP-glucuronosyltransferase (UGT) enzymes is a predictor of drug-induced liver injury, Hepatology, 2024, 10.1097
  5. TJ. Liao, B. Pan, H. Hong, P. H. Hayashi, J. A. Rule, D. Ganger, W. M. Lee, J. Rakela, M. Chen: Whole exome sequencing reveals genetic variants in HLA class II genes associated with transplant-free survival of indeterminate acute liver failure. Clin. Transl. Gastroenterol., 2022, 10, 14309
  6. R. Moore, K. Ashby, TJ. Liao, M. Chen: Machine Learning to Identify Interaction of Single-Nucleotide Polymorphisms as a Risk Factor for Chronic Drug-Induced Liver Injury. Int. J. Environ. Res. Public Health, 2021, 18(20), 10603
  7. TJ. Liao, H. Jang, D. Fushman, R. Nussinov: SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations. J. Chem. Phys., 2020, 153(4), 045106
  8. TJ. Liao, H. Jang, R. Nussinov, D. Fushman: High-affinity Interactions of the nSH3/cSH3 Domains of Grb2 with the C-terminal Proline-rich Domain of SOS1. J. Am. Chem. Soc., 2020, 142 (7), 3401-3411
  9. R. Nussinov, M. Zhang, CJ. Tsai, TJ. Liao, D. Fushman, H. Jang: Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: A comprehensive review underscoring the challenges in pharmacological intervention. Biophysical reviews, 2018, 1-20
  10. TJ. Liao, H. Jang, D. Fushman, R. Nussinov: Allosteric KRas4B can modulate SOS1 fast and slow activation cycles. Biophysical Journal, 2018, 115 (4), 629-641
  11. TJ. Liao, H. Jang, CJ. Tsai, D. Fushman, R. Nussinov: The dynamics mechanism of RASSF5 and MST kinase activation by Ras. Physical Chemistry Chemical Physics, 2017, 19, 6470-6480
  12. R. Nussinoc, H. Jang, CJ. Tsai, TJ. Liao, S. Li, D. Fushman & J. Zhang: Intrinsic protein disorder in oncogenic KRas signaling. Cellular and Molecular Life Science, 2017, 74(17):3245-3261
  13. TJ. Liao, CJ. Tsai, H. Jang, D. Fushman, R. Nussinoc: RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro. Current Opinion in Structural Biology, 2016, 41:217-224​

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