李秀珠

李秀珠  研究員
生技與藥物研究所
Email: slee@nhri.edu.tw

 

EDUCATION

• Ph.D., Biochemistry & Molecular Biology, University of Texas, Southwestern Medical Center, USA
• M.S., Plant Pathology, National Taiwan University, Taiwan
• B.S., Plant Pathology, National Chung-Hsing University, Taiwan

PROFESSIONAL EXPERIENCES

• Investigator, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan (2021-present)
• Associate Investigator, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan (2006-2020)
• Assistant Investigator, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan (2002-2006)
• Head of High Throughput Screening Core for Drug discovery, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan (2002-2005)
• Research Scientist, Invitrogen, Invitrogen co. (2000-2002)
• Associate Research Scientist, Invitrogen co./ Research Genetics Inc. (1999-2000)

RESEARCH INTERESTS

Dr. Lee’s biology lab works on “drug discovery and development for anti-cancers, anti-coronaviruses, and anti-inflammatory diseases” as well as “molecular pharmacology, biochemistry & molecular biology, and chemical biology.”

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Dr. Lee had made efforts in drug discovery project for anti-cancers, anti-coronoviruses, anti-inflammatory diseases, and identified classes of lead compounds. With the obtained compounds, Dr. Lee has focused on developing phenanthroindolizidines and derived dibenzoquinolines into therapeutic agents for anti-inflammatory related diseases, anti-coronaviruses, and anti-cancers. These results have been published and obtained patents in US and other countries.

Dr. Lee has also engaged in discovery and development of natural products for therapeutic agents and related studies and resulted in a track of publications. Moreover, Dr. Lee also has a research interest in studying how metabolisms changes in diseases and seeking approaches for the therapy.

SELECTED PUBLICATIONS

1. Yue-Zhi Lee^#, Hsing-Yu Hsu^#, Cheng-Wei Yang^#, Yi-Ling Lin^#, Sui-Yuan Chang^#, Ruey-Bing Yang, Jian-Jong Liang, Tai-Ling Chao, Chun-Che Liao, Han-Chieh Kao, Jang-Yang Chang 1, Huey-Kang Sytwu, Chiung-Tong Chen, Shiow-Ju Lee*. The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b. Pharmaceutics 2022 Jul 21;14(7):1511. doi: 10.3390/14071511. (Corresponding author).
2. Cheng-Wei Yang, Yue-Zhi Lee, Hsing-Yu Hsu, Guan-HaoZhao, Shiow-Ju Lee*. Tyrphostin AG1024 suppresses coronaviral replication by downregulating JAK1 via an IR/IGF-1R independent proteolysis mediated by Ndfip1/2_NEDD4-like E3 ligase ITCH. Pharmaceuticals (Basel) 2022, 17;15(2):241. doi: 10.3390/ph15020241. (Corresponding author)
3. Hsing-Yu Hsu^#, Cheng-Wei Yang^#, Yue-Zhi Lee^#, Yi-Ling Lin^#, Sui-Yuan Chang^#, Ruey-Bing Yang, Jian-Jong, Liang, Tai-Ling Chao, Chun-Che Liao, Han-Chieh Kao, Szu-Huei Wu, Jang-Yang Chang, Huey-Kang Sytwu, Chiung-Tong Chen, Shiow-Ju Lee*. Remdesivir and cyclosporine synergistically inhibit the human coronaviruses OC43 and SARS-CoV-2. Frontiers in Pharmacology 2021, 12:706901. doi: 10.3389/fphar.2021.706901  (Corresponding author)
4. Cheng-Wei Yang^#, Yue-Zhi Lee^#, Hsing-Yu Hsu^#, Jia-Tsrong Jan^#, Yi-Ling Lin^#, Sui-Yuan Chang^#, Tzu-Ting Pen5, Ruey-Bing Yang, Jian-Jong, Liang, Chun-Che Liao, Tai-Ling Chao, Yu-Hau Pang, Han-Chieh Kao, Wen-Zheng Huang, Jiunn-Horng Lin, Chun-Ping Chang, Guang-Hao Niu, Szu-Huei Wu, Kung-Yee Liang, Huey-Kang Sytwu, Chiung-Tong Chen, Shiow-Ju Lee*. Inhibition of SARS-CoV-2 by highly potent broad-spectrum anti-coronaviral tylophorine-based derivatives. Frontiers in Pharmacology, 2020, 11:606097. https://doi.org/10.3389/fphar.2020.606097 (Corresponding author)
5. Cheng-Wei Yang, Hsing-Yu Hsu, Hsin-Yu Chang, Yue-Zhi Lee, Shiow-Ju Lee*. Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na⁺/K⁺-ATPase independent proteolysis. Biochemical Pharmacology 2020, (180) 114122. DOI:10.1016/j.bcp.2020.114122. (Corresponding author)
6. Cheng-Wei Yang^#, Tzu-Ting Peng^#, Hsing-Yu Hsu^#, Yue-Zhi Lee^#, Szu-Huei Wu, Wen-Hsing Lin, Yi-Yu Ke, Tsu-An Hsu, Teng-Kuang Yeh, Wen-Zheng Huang, Jiunn-Horng Lin, Huey-Kang Sytwu, Chiung-Tong Chen*, Shiow-Ju Lee*. Repurposing old drugs as antiviral agents for coronaviruses. Biomedical Journal, 2020, 368-374. https://doi.org/10.1016/j.bj.2020.05.003 (Co-corresponding author)
7. Guan-Hao Zhao, Ya-Qi Qiu, Cheng-Wei Yang, Ih-Sheng Chen, Chin-Yu Chen, Shiow-Ju Lee*. The cardenolides ouabain and reevesioside A promote FGF2 secretion and subsequent FGFR1 phosphorylation via converged ERK1/2 activation. Biochemical Pharmacology 2020, 172,113741. https://doi.org/10.1016/j.bcp.2019.113741 (Corresponding author)
8. Yue-Zhi Lee, Huan-Chen Guo, Guan-Hao Zhao, Cheng-Wei Yang, Hsin-Yu Chang, Ruey-Bing Yang, Linyi Chen, Shiow-Ju Lee*. Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1α. Pharmacological Research 2020, 152, 104581. https://doi.org/10.1016/j.phrs.2019.104581 (Corresponding author)
9. Cheng-Wei Yang, Hsin-Yu Chang, Yue-Zhi Lee, Hsing-Yu Hsu, Shiow-Ju Lee*. The cardenolide ouabain suppresses coronaviral replication via augmenting a Na⁺/K⁺-ATPase-dependent PI3K_PDK1 axis signaling. Toxicology and Applied Pharmacology. 2018 (356) ,90-97. https://doi.org/10.1016/j.taap.2018.07.028 (Corresponding author)
10. Teng-Kuang Yeh^#, Ching-Chuan Kuo^#, Yue-Zhi Lee^#, Yi-Yu Ke^#, Kuang-Feng Chu^#, Hsing-Yu Hsu, Hsin-Yu Chang, Yu-Wei Liu, Jen-Shin Song, Cheng-Wei Yang, Li-Mei Lin, Manwu Sun, Szu-Huei Wu, Po-Chu Kuo, Chuan Shih, Chiung-Tong Chen, Lun Kelvin Tsou*, Shiow-Ju Lee*. Design, synthesis, and evaluation of 2,4-thiazolidinedione derivatives as a novel class of glutaminase inhibitors. Journal of Medicinal Chemistry, 2017, 60 (13), 5599–5612. (Co-corresponding author)
11. Cheng-Wei Yang, Yue-Zhi Lee, Shin-Yu Shih, Chuan Shih, Yu-Sheng Chao, Hwan-You Chang, Shiow-Ju Lee* Targeting Nucleocapsid Associated Coronaviral Ribonucleoprotein Complex and Cellular JAK2 Mediated Dominant NF-kB Activation for a Cooperatively Ultimate Anticoronaviral Activity treatment strategy. Scientific Reports, 2017, Article number: 4105. www.nature.com/articles/s41598-017-04203-9 (Corresponding author)
12. Cheng-Wei Yang, Hsin-Yu Chang, Yue-Zhi Lee, Shin-Yu Shih, Hsun-Shuo Chang, Ih-Sheng Chen, Shiow-Ju Lee*. Identification of anti-viral activity of the cardenolides, Na⁺/K⁺-ATPase inhibitors, against porcine transmissible gastroenteritis virus. Toxicology and Applied Pharmacology, 2017 (332), 129-137. DOI: 10.1016/j.taap.2017.04.017 (Corresponding author)
13. Ya-Qi Qiu, Cheng-Wei Yang, Yue-Zhi Lee, Ruey-Bing Yang, Chih-Hao Lee, Hsing-Yu Hsu, Chien-Chung Chang, and Shiow-Ju Lee*. Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget. Oncotarget, 2015, 6(4): 2148-2163. (Corresponding author)
14. Yue-Zhi Lee#, Cheng-Wei Yang#, Hsin-Yu Chang#, Hsing-Yu Hsu#, Ih-Shen Chen, Hsun-Shuo Chang, Chih-Hao Lee, Jinq-chyi Lee, Chidambaram Ramesh Kumar, Ya-Qi Qiu, Yu-Sheng Chao and Shiow-Ju Lee*. Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells Oncotarget, 2014, 5(15): 6087-6101. (Corresponding author)
15. Cheng-Wei Yang, Yue-Zhi Lee, Hsing-Yu Hsu, Chia-Mao Wu, Hwan-You Chang, Yu-Sheng Chao, Shiow-Ju Lee*. c-Jun-mediated anti-cancer mechanisms of tylophorine. Carcinogenesis, 2013, 34(6):1304-1314. (Corresponding author)
16. Hsun-Shuo Chang, Michael Y. Chiang, Hsing-Yu Hsu, Cheng-Wei Yang, Shiow-Ju Lee*, and Ih-Sheng Chen*. Cytotoxic Cardenolide Glycosides from the Root of Reevesia formosana. Phytochemistry, 2013, 87:86-95. (Co-corresponding author)
17. Yue-Zhi Lee, Cheng-Wei Yang, Hsing-Yu Hsu, Ya-Qi Qiu, Teng-Kuang Yeh, Hsin-Yu Chang, Yu-Sheng Chao, Shiow-Ju Lee*. Synthesis and Biological Evaluation of Tylophorine-Derived Dibenzoquinolines as Orally Active Agents–Exploration of the Role of Tylophorine E Ring on Biological Activity. Journal of Medicinal Chemistry. 2012, 55: 10363-77. (Corresponding author)
18. Yue-Zhi Lee,#, Chun-Wei Huang,#, Cheng-Wei Yang, Hsing-Yu Hsu, Iou-Jiun Kang, Yu-Sheng Chao, Ih-Sheng Chen, Hwan-You Chang, and Shiow-Ju Lee* Isolation and evaluation of biological activities of phenanthroindolizidine and septicine alkaloids from Formosa Tylophora ovata. Planta Medica, 2011; 77: 1932–1938. (Corresponding author)
19. Cheng-Wei Yang, Yue-Zhi Lee, Iou-Jiun Kang, Dale L. Barnard, Jia-Tsrong Jan, Du Lin, Chun-Wei Huang, Teng-Kuang Yeh, Yu-Sheng Chao, Shiow-Ju Lee*. (Corresponding author) Identification of Phenanthroindolizines and Phenanthroquinolizidines as Novel Potent Anti-Coronaviral Agents for Porcine Enteropathogenic Coronavirus Transmissible Gastroenteritis Virus and Human Severe Acute Respiratory Syndrome Coronavirus. Antiviral Research, 2010, NOV, 88:160-168. (Corresponding author)
20. Chia-Mao Wu, Cheng-Wei Yang, Yue-Zhi Lee, Ta-Hsien Chuang, Pei-Lin Wu, Yu-Sheng Chao, Shiow-Ju Lee*. Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression. Biochemical and Biophysical Research Communications 2009, 386 (1), 145-150. (Corresponding author)
21. Yue-Zhi Lee, Cheng-Wei Yang, Iou-Jiun Kang, Ssu-Hui Wu, Yu-Sheng Chao, Jyh-Haur Chern, Shiow-Ju Lee*. Dual functions of 2-phenyl-ethenesulfonic acid phenyl ester analogues inhibiting expression of inducible nitric oxide synthase and activating peroxysome proliferator-activated receptor g. Bioorganic & Medicinal Chemistry Letters. 2008, (18), 5676-5679. (Corresponding author)
22. Cheng-Wei Yang, Yung-Ning Yang, Po-Huang Liang, Chi-Min Chen, Wei-Liang Chen, Hwan-You Chang, Yu-Sheng Chao, &, Shiow-Ju Lee*. Identification of Novel Small-Molecule Inhibitors of Transmissible Gastroenteritis Virus. Antimicrobial Agents and Chemotherapy. 2007, 51 (11), 3924-3931. (Corresponding author)
23. Cheng-Wei Yang, Ta-Hsien Chuang, Pei-Lin Wu, Wen-Hsin Huang, Shiow-Ju Lee*. Anti-Inflammatory Effects of 7-Methoxycryptopleurine and Structure-Activity Relations of Phenanthroindolizidines and Phenanthroquinolizidines. Biochemical and Biophysical Research Communications 354(4):942-8, 2007. (Corresponding author)
24. Cheng-Wei Yang, Wei-Liang Chen, Huan-Yi Tseng, Pei-Lin Wu, Shiow-Ju Lee*. Anti-inflammatory Mechanisms of Phenanthroindolizidine Alkaloids. Molecular Pharmacology. 2006. 69(3): 749-758. (Corresponding author)
25. Huan-Yi Tseng, Ssu-Hui Wu, Wen-Hsin Huang, Shao-Fang Wang, Yung-Ning Yang, Neeraj Mahindroo, Tsu Hsu, Weir-Torn Jiaang, Shiow-Ju Lee*. Benzothiazolium Compounds: Novel Classes of Inhibitors That Suppress the Nitric Oxide Production in RAW264.7 Cells Stimulated by LPS/IFN Bioorganic & Medicinal Chemistry Letters, 2005, 15 (8): 2027-2032. (Corresponding author)
26. I-Lin Lu ^#, Shiow-Ju Lee ^#, Hsau Ysua ^#, Su-Ying Wu, Kuo-His Kao, Chia-Hui Chien, Ying-Ying Chang, Yuan-Shou Chen, Jai-Hong Cheng, Chung-Nien Chang, Tung-Wei Chen, Sheng-Ping Chang, Xin Chen, and Weir-Torn Jiaang*. Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors. Bioorganic and Medicinal Chemistry Letters, 15（13）：3271-3275, 2005. (# Co-first author)
27. Jing-Ping Liou, Yi-Ling Chang, Fu-Ming Kuo, Chun-Wei Chang, Huan-Yi Tseng, Chiung-Chiu Wang, Yung-Ning Yang, Jang-Yang Chang, Shiow-Ju Lee*, and Hsing-Pang Hsieh*. Concise Synthesis and Structure-Activity Relationship of 1-Aroylindoles and 3-Aroylindoles, Combretastatin A-4 Analogues, as a Novel Class of Potent Antitubulin Agents. Journal of Medicinal Chemistry 2004. 47: 4247-4257. (Co-correspondent author).

 OTHER PUBLICATIONS :

28. Hui-Chen Hung, Yi-Yu Ke, Sheng-Yu Huang, Peng-Nien Huang, Yu-An Kung, Teng-Yuan Chang, Kuei-Jung Yen, Tzu-Ting Peng, Shao-En Chang, Chin-Ting Huang, Ya-Ru Tsai, Szu-Huei Wu, Shiow-Ju Lee, Jiunn-Horng Lin, Bing-Sin Liu, Wang-Chou Sung, Shin-Ru Shih, Chiung-Tong Chen, and John Hsu. Discovery of M Protease inhibitors encoded by SARS-CoV-2. Antimicrobial Agents and Chemotherapy, 2020, Volume 64 Issue 9 e00872-20. DOI: 10.1128/AAC.00872-20
29. Yi-Yu Ke, Tzu-Ting Peng, Teng-Kuang Yeh, Wen-Zheng Huang, Shao-En Chang, Szu-Huei Wu, Hui-Chen Hung, Tsu-An Hsu, Shiow-Ju Lee, Jeng-Shin Song, Wen-Hsing Lin, Tung-Jung Chiang, Jiunn-Horng Lin, Huey-Kang Sytwu, Chiung-Tong Chen. Artificial Intelligence Approach Fighting COVID-19 with Repurposing Drugs. Biomedical Journal, 2020, 355-362. https://doi.org/10.1016/j.bj.2020.05.001
30. Fang-Yi Yu, Chiu-Min Chiua, Yue-Zhi Lee, Shiow-Ju Lee, Chien-Ming Chou, Bang-Jau Youc, Dai-Keng Hsieh, Maw-Rong Lee, Richard M. Bostock,* and Miin-Huey Lee,*. Antibiotic activity and polyketide synthase genes in Monilinia fructicola. Phytopathology, 2020 Aug;110(8):1465-1475. https://doi.org/10.1094/PHYTO-02-20-0059-R
31. Hsun-Shuo Chang, Chu-Hung Lin, Pei-Yu Hsiao, Hung-Ti Peng, Shiow-Ju Lee, Ming-Jen Cheng and Ih-Sheng Chen*. Bioactive Composition of Reevesia formosana Root and Stem with Cytotoxic Activity Potential. RSC Advances, 2017, 7, 27040-27047. DOI:10.1039/C7RA04255H.
32. Pei-Yu Hsiao, Shiow-Ju Lee, Ih-Sheng Chen, Hsing-Yu Hsu, Hsun-Shuo Chang. Cytotoxic cardenolides and sesquiterpenoids from the fruits of Reevesia formosana. Phytochemistry, 2016, Oct, 130:282-290.
33. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A……Lee SJ ….., et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.
34. Shan-Yu Lin, Horng-Huey Ko, Shiow-Ju Lee, Hsun-Shuo Chang, Chu-Hung Lin, and Ih-Sheng Chen. Biological Evaluation of Secondary Metabolites from the Root of Machilus obovatifolia. Chem Biodivers. 2015 Jul;12(7):1057-67.
35. Chi-Chen Yang, Han-Shu Hu, Ren-Huang Wu, Szu-Huei Wu, Shiow-Ju Lee, Weir-Torn Jiaang, Jyh-Haur Chern, Chung-Ming Chang, and Andrew Yueh. Discovery of a Novel Dengue Virus NS2B/NS3 Protease Inhibitor, BP13944, through High-Throughput Screening with Dengue Replicon Cells. Antimicrobial Agents and Chemotherapy. 2014 Jan;58(1):110-119.
36. Chun-Po Chang, Hsun-Shuo Chang, Chien-Fang Peng, Shiow-Ju Lee, Ih-Sheng Chen. Antitubercular Resorcinol Analogs and Benzenoid C-Glucoside from the Roots of Ardisia cornudentata. Planta Medica, 2011. 77:60-65.
37. Chi-Chen Yang, Yi-Chen Hsieh, Shiow-Ju Lee, Szu-Huei Wu, Ching-Len Liao, Chang-Huei Tsao, Yu-Sheng Chao, Jyh-Haur Chern, Chung-Pu Wu, and Andrew Yueh. Novel Dengue Virus-Specific NS2B/NS3 Protease Inhibitor, BP2109, Discovered by a High-Throughput Screening Assay. Antimicrob. Agents Chemother., 2011(5):229-238.
38. Hsun-Shuo Chang, Shiow-Ju Lee, Cheng-Wei Yang, and Ih-Sheng Chen. Cytotoxic Sesquiterpenes from Magnolia kachirachirai. Chenistry & Biodiversity. 2010 Nov (7):2737-2747.
39. Tsung-Hsien Chou, Jih-Jung Chen, Shiow-Ju Lee, Michael Y. Chiang, Cheng-Wei Yang, and Ih-Sheng Chen. Cytotoxic Flavonoids from the Leaves of Cryptocarya chinensis. 2010, Aug 12, Journal of Natural Product. 24(7):647-656.
40. Ming-Jen Cheng, Tzu-Ann Wang, Shiow-Ju Lee, Ih-Sheng Chen. New butanolide and a new secobutanolide from Litsea lii var. nunkaotahangensis. Natural Product Research. 2010 Apr 20;24(7):647-656.
41. Hsun-Shuo Chang, Yi-Ju Lin, Shiow-Ju Lee, Cheng-Wei Yang, Wei-Yu Lin, Ian-Lih Tsai, Ih-Sheng Chen*. Cytotoxic alkyl benzoquinones and alkyl phenols from Ardisia virens. Phytochemistry, 2009 (70), 2064-2071.
42. Yang CH, Cheng MJ, Lee SJ, Yang CW, Chang HS, Chen IS. Secondary metabolites and cytotoxic activities from the stem bark of Zanthoxylum nitidum. Chem Biodivers. 2009 Jun;6(6):846-57. (SCI)
43. Su, TJ;,Chang, HS; Peng, CF; Lee, SJ; Chen, IS. Antitubercular resorcinols and cytotoxic alkyl benzoquinones from Ardisia kusukuensis Taiwan Pharmaceutical Journal. 2009 Dec;61(4):89-105.
44. Chia-Yuan Liu, Yang-Wen Chen, Ming-Jen Cheng, Shoiw-Ju Lee, Mohamed h. Abd el-Razek, Wen-Hsiung Chang, Yu-Jen Chen, and Ih-Sheng Chen. Cytotoxic constituents from the root wood of formosan Michelia compressa. Journal of the Chilean Chemical Society. 2008, 53(2):1523-1524.
45. Su-Yen Chang, Ming-Jen Cheng, Yueh-Hsiung Kuo, Shiow-Ju Lee, Hsun-Shuo Chang, and Ih-Sheng Chen. Secondary metabolites from the stem bark of Litsea akoensis and Their Cytotoxic activity. 2008, 91:1156-1165. Helvetica Chimica Acta.
46. Tzu-Ann Wang, Ming-Jen Cheng, Shiow-Ju Lee, Cheng-Wei Yang, Hsun-Shuo Chang, and Ih-Sheng Chen*. Secondary metabolites from the Leaves of Litsea lii var. nunkao-tahangensis. 2008, 91:1036-1044. Helvetica Chimica Acta.
47. I-Lin Lu, Keng-Chang Tsai,Yi-Kun Chiang, Weir-Torn Jiaang, Ssu-Hui Wu,  Chia-Hui Chien, Shiow-Ju Lee, Xin Chen, Yu-Sheng Chao, and Su-Ying Wu*. “A Three-Dimensional Pharmacophore Model for Dipeptidyl Peptidase IV Inhibitors” European Journal of Medicinal Chemistry 2008 (43) :1603-1611
48. Yu-Chang Chen, Ming-Jen Cheng, Shiow-Ju Lee, Ian-Lih Tsai, and Ih-Sheng Chen. Chemical Constituents from the Root of Antidesma pentandrum var. barbatum. Journal of the Chinese Chemical Society, 2007, 54, 1325-1332.
49. Mohamed H. Abd El-Razeka, Hsun-Shuo Chang, Shiow-Ju Lee, Ian-Lih Tsai, Ih-Sheng Chen. Biphenyls from Pourthiaea lucida. Biochemical Systematics and Ecology 35:248-250, 2007.
50. Hong, B-C, Y-F Jiang, Y-L Chang, S-J Lee. Synthesis and Cytotoxicity Studies of Cyclohepta[b]indoles, Benzo[6,7]cyclohepta[1,2-b]indoles, Indeno[1,2-b]indoles, and Benzo[a]carbazoles. J. Chin. Chem. Soc. 2006. 53(3):647-662.
51. Ta-Hsien Chuang, Shiow-Ju Lee, Cheng-Wei Yang and Pei-Lin Wu. Expedient Synthesis and Structure-Activity Relationships of Phenanthroindolizidine and Phenanthroquinolizidine Alkaloids . Organic & Biomolecular Chemistry. 2006 (4), 860-867.
52. Tsu, H.; Chen, X.; Chen, C.-T.; Lee, S.-J.; Chang, C.-N.; Kao, K.-H.; Coumar, M. S.; Yeh, Y.-T.; Chien, C.-H.; Wang, H.-S.; Lin, K.-T.; Chang, Y.-Y.; Wu, S.-H.; Chen, Y.-S.; Lu, I.-L.; Wu, S.-Y.; Tsai, T.-Y.; Chen, W.-C.; Hsieh, H.-P.; Chao, Y.-S.; Jiaang, W.-T.2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: A Potent, Selective, and Orally Bioavailable Dipeptide-Derived Inhibitor of Dipeptidyl Peptidase IV. J. Med. Chem.; (Article); 2006; 49(1); 373-380.
53. Jaya Vatsyayan, Shiow-Ju Lee, and Hwan-You Chang. Effects of xenobiotics and peroxisome proliferator-activated receptor- on the human UDPglucose dehydrogenase gene expression. Journal of Biochemical and Molecular Toxicology, 2005,19 (5):279-288. (SCI)
54. Yeh-Long Chen , Chih-Ming Lu, Shoiw-Ju Lee, Daih-Huang Kuo, I-Li Chen, Tai-Chi Wang, and Cherng-Chyi Tzeng. Synthesis, antiproliferative, and vasorelaxing evaluations of coumarin alpha-methylene-gamma-butyrolactones. Bioorg Med Chem, 13 (20): 5710-5716. 2005.
55. Ming-Jen Cheng, Ian-Lih Tsai, Shiow-Ju Lee, Bolleddula Jayaprakasam, Ih-Sheng Chen. Steryl epoxide, secobutanolide and butanolides from the stem wood of Machilus zuihoensis. Phytochemistry. 2005, 1180-1185.
56. Gerco Hassink, Marjolein Kikkert, Sjaak van Voorden, Shiow-Ju Lee, Robbert Spaapen, Theo van Laar, Eric Bartee, Klaus Früh, Vincent Chau, Emmanuel Wiertz. TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum . Biochem. J. 2005.388: 647-55.
57. Weir-Torn Jiaang, Yuan-Shou Chen, Hsu Tsu, Szu-Hui Wu, Chia-Hui Chien, Chung-Nien Chang, Sheng-Ping Chang, Shiow-Ju Lee, Xin Chen, Novel Isoindoline Compounds For Potent and Selective Inhibition of Prolyl Dipeptidase DPP8, Bioorganic & Medicinal Chemistry Letters, 2005, 15:687-691.
58. Chen, Y-C, M-J Cheng, S-J Lee, A. K. Dixit, T. Ishikawa, I-L Tsai, and I-S Chen. Dixanocoumarins from the root of Formosan Antidesma pentandrum var. barbatum. Helvetica Chimica Acta. 87:2805-2811, 2004.
59. Kuo, C-C, H-P Hsieh, W-Y Pan, C-P Chen, J-P Liou, S-J Lee, Y-L Chang, L-T Chen, C-T Chen and J-Y Chang. BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo. Cancer Research 2004, 64: 4621-4628
60. Wu, P-L., Lin, F-W., Wu, T-S., Kuoh, C-S., Lee, K-H., and Lee, S.-J. Cytotoxic and anti-HIV Principles from the Rhizomes of Begonia nantoensis. Chem. Pharm. Bull. 2004, 52(3):345-349.
61. Cheng, M-J., Lee, S-J., Chang, Y-Y., Wu, S-H., and Tsai, I-L. Jayaprakasam,B. Chen, I-S. Chemical and Cytotoxic Constituents from Peperomia sui. Phytochemistry, 2003,63:603-608.
62. Lan, Y-H., Chang, F-R., Yu, J-H., Yang, Y-L., Chang, Y-L., Lee, S-J., and Wu, Y-C. Cytotoxic Styrylpyrones from Goniothalamus amuyon”, Journal of Natural Product. 2003, 66:487-490. (SCI)
63. Lee, S. -J*. L. E. Varnavas, and R. J. Zachorchak. 2002. Biological Implication of Genes Differentially Expressed in Human Hippocampus and Spinal Cord. Journal of Biochemistry, Molecular Biology and Biophysics 6(2):135-41. (first and correspondent author)
64. Lee, S. -J*. Beckingham, K. and Stull, J. T. 2001. Ca²⁺-Independent Activity of Nitric Oxide Synthase. Biochemical and Biophysical Research Communications 284(2), 526-530. (first and correspondent author)
65. Lee, S. -J. * Beckingham, K. and Stull, J. T. 2000. Mutations at Lysine 525 of Inducible Nitric Oxide Synthase Affect its Ca²⁺-independent Activity. J. Biol. Chem. 275(46):36067-36072. (first and correspondent author)
66. Lee, S. -J. and Stull, J. T. 1998. Calmodulin-dependent Regulation of Inducible and Neuronal Nitric-Oxide Synthase. J.Biol.Chem. 273(42):27430-27437. (first author)
67. Chuang, T. Y., and Lee, S. -J. Comparison of Cultural Characters of Fusarium oxysporum f. sp. Cubense. on Differential Medium. Plant Pathol. Bull. 4:129-135. (Taiwan, R.O.C.)
68. Lee, S. -J. and Chuang, T. Y. 1991. Factors Affecting Variation of Fusarium oxysporum sp. Cubense. Plant Prot. Bull. 33:167-179. (Taiwan, R.O.C.) (first author)
69. Lee, S. -J. and Chuang, T. Y, 1990 Survival of Wild Type and Pionnotal Type of Fusarium oxysporum sp. Cubense Race 4 in Soil. Plant Prot. Bull. 32:298-306. (Taiwan, R.O.C.) (first author)
70. Wu, W. C., S. H. Ju, -J. Lee, H. I. Huang, B. C. Yang, H. F. Kuo, and Y. K. Hsueh. 1986. Variations in Xanthomonos compestris pv. citri.  Plant Prot. Bull 28:241-252. (Taiwan, R.O.C.)
71. Wu, W. C., H.I. Maa, and -J. Lee. 1986. An Agar Medium Suitable for Growth of Xanthomonas pv citri. Plant Prot, Bull. 28:225-228. (Taiwan, R.O.C.)

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   DBPR108團隊: 蔣維棠、陳炯東、陳新、葉燈光、趙宇生、伍素瑩、宋政勳、李秀珠、楊宗德、龔一秦、藍始榮、徐紹熾、朱筱文、李逸芳與楊珮雅
3. 2013_[傑出學者養成計畫(個別型)]
   以化學探針探討娃兒藤生物鹼之生物標靶_兼研究娃兒藤生物鹼對其生物標靶之影響在抗癌機轉之角色(NSC 102-2628-B-400 -002 -MY3 )

PATENTS：

1.已獲得專利:

2.申請中專利:
美國及台灣正式專利申請:
-編號:C-1090008US & C-1090008TW 2021/07/08 filed
-專利名稱:INHIBITORS OF POSITIVE STRAND RNA VIRUSES/正股核糖核酸病毒之抑制劑