伍素瑩

SY Wu 2伍素瑩  研究員
生技與藥物研究所
Email: suying@nhri.edu.tw

 


EDUCATION

  • Ph.D., Structural Biochemistry, University of Edinburgh, Edinburgh, UK (1995)
  • B.S., Chemistry, National Taiwan University, Taipei, Taiwan (1990)

PROFESSIONAL EXPERIENCES

  • Investigator, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan (2011-present)
  • Associate Investigator, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan (2006-2011)
  • Assistant Investigator, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taiwan (2002-2006)
  • Postdoctoral Fellow, University of Edinburgh, UK (1999-2001)

RESEARCH INTERESTS

The main research interests in Dr. Wu’s lab are to effectively identify drug hits by advanced structure-based virtual screening and computer-aided drug design technology. The interactions of drug hits with the target proteins are studied by x-ray protein crystallography to facilitate the further drug lead optimization.

RESEARCH ACTIVITIES & ACCOMPLISHMENTS

Structure-based drug design has played an important role in the drug discovery process because of its efficiency to reduce the high cost and wastage in time and money to discover a novel drug. This approach promises the development of drugs which have more specificity toward the targets and fewer side effects, since the lead compounds can be modified atom by atom to fit their specific targets by visualizing the three-dimensional structure of the target protein-drug complex using x-ray crystallographic technology. Dr. Wu’s lab works closely with other labs, including chemistry, molecular biology, pharmacology labs in the Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, to discovery and develop novel anti-diabetics, anti-virus and anti-cancer drugs.

SELECTED PUBLICATIONS

  1. Lung-Chun Lee; Yi-Hui Peng; Hsin-Huei Chang; Tsu Hsu; Cheng-Tai Lu; Chih-Hsiang Huang; Ching-Cheng Hsueh; Fang-Chun Kung; Ching-Chuan Kuo*; Weir-Torn Jiaang* and Su-Ying Wu* (Corresponding author) “ Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2)” (2021) Journal of medicinal chemistry (Online publication: 2 Aug, 2021)
  2. Yi-Hui Peng; Fang-Yu Liao; Chen-Tso Tseng; Ramajayam Kuppusamy; An-Siou Li; Chi-Han Chen; Yu-Shiou Fan; Sing-Yi Wang; Mine-Hsine Wu; Ching-Cheng Hsueh; Jia-Yu Chang; Lung-Chun Lee; Chuan Shih; Kak-Shan Shia; Teng-Kuang Yeh; Ming-Shiu Hung; Ching-Chuan Kuo; Jen-Shin Song; Su-Ying Wu*(Corresponding author); Shau-Hua Ueng* “ Unique Sulfur–Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors” (2020) Journal of medicinal chemistry 63 (4), pp 1642-1659
  3. Wen-Hsing Lin, Su-Ying Wu ( co-first author), Teng-Kuang Yeh, Chiung-Tong Chen, Jen-Shin Song, Hui-Yi Shiao, Ching-Chuan Kuo, Tsu Hsu, Cheng-Tai Lu, Pei-Chen Wang, Tsung-Sheng Wu, Yi-Hui Peng, Hui-You Lin, Ching-Ping Chen, Ya-Ling Weng, Fang-Chun Kung, Mine-Hsine Wu, Yu-Chieh Su, Kuo-Wei Huang, Ling-Hui Chou, Ching-Cheng Hsueh, Kuei-Jung Yen, Po-Chu Kuo, Chen-Lung Huang, Li-Tzong Chen, Chuan Shih, Hui-Jen Tsai, * Weir-Torn Jiaang* “ Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia” (2019) Journal of medicinal chemistry 62 (24), pp 11135-11150
  4. Tsung-Sheng Wu, Wen-Hsing Lin, Hui-Jen Tsai, Ching-Cheng Hsueh, Tsu Hsu, Pei-Chen Wang, Hui-You Lin, Yi-Hui Peng, Cheng-Tai Lu, Lung-Chun Lee, Chih-Hsiang Tu, Fang-Chun Kung, Hui-Yi Shiao, Teng-Kuang Yeh, Jen-Shin Song, Jia-Yu Chang, Yu-Chieh Su, Li-Tzong Chen, Chiung-Tong Chen, Weir-Torn Jiaang, * and Su-Ying Wu* (Corresponding author) “Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants “(2019) J. Med. Chem. (Online publication: 10 Apr, 2019)
    This paper has been selected to be featured in ACS Editors’ Choice https://pubs.acs.org/editorschoice/
  5. Chih-Hsiang Tu, Wen-Hsing Lin, Yi-Hui Peng, Tsu Hsu, Jian-Sung Wu, Chun-Yu Chang, Cheng-Tai Lu, Ping-Chiang Lyu, Chuan Shih, Weir-Torn Jiaang, and Su-Ying Wu * (Corresponding author) “Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK)” (2016) J. Med. Chem. Publication Date (Web): March 31, 2016 (10.1021/acs.jmedchem.6b00106)
  6. Yi-Hui Peng, Shau-Hua Ueng, Chen-Tso Tseng, Ming-Shiu Hung, Jen-Shin Song, Jian-Sung Wu, Fang-Yu Liao, Yu-Shiou Fan, Mine-Hsine Wu, Wen-Chi Hsiao, Ching-Cheng Hsueh, Shu-Yu Lin, Chia-Yi Cheng, Chih-Hsiang Tu, Lung-Chun Lee, Ming-Fu Cheng, Kak-Shan Shia, Chuan Shih, and Su-Ying Wu* (Corresponding author). Important Hydrogen Bond Networks in Indoleamine 2,3-dioxygenase 1 (IDO1) Inhibitor Design revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1. (2016) J. Med. Chem. 59 (1): 282-293.
  7. Jian-Sung Wu, Shu-Yu Lin, Fang-Yu Liao, Wen-Chi Hsiao, Lung-Chun Lee, Yi-Hui Peng, Chia-Ling Hsieh, Ming-Hsine Wu, Jen-Shin Song, Andrew Yueh, Chun-Hwa Chen, Shiu-Hwa Yeh, Chia-Yeh Liu, Shu-Yi Lin, Teng-Kuang Yeh, Tsu-An Hsu, Chuan Shih, Shau-Hua Ueng, Ming-Shiu Hung, and Suying Wu* (Corresponding author) “Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening”. (2015) J. Med. Chem. 58 (19), pp 7807-7819.
  8. Yi-Hui Peng , Hui-Yi Shiao , Chih-Hsiang Tu , Pang-Min Liu , John Tsu-An Hsu , Prashanth Kumar Amancha , Jian-Sung Wu , Mohane Selvaraj Coumar , Chun-Hwa Chen , Sing-Yi Wang , Wen-Hsing Lin , Hsu-Yi Sun , Yu-Sheng Chao , Ping-Chiang Lyu ‡, Hsing-Pang Hsieh*, and Su-Ying Wu* (Corresponding author) “Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors”   (2013) J. Med. Chem. Publication Date (Web): April 23, 2013
  9. Jiun-Ming Wu, Chiung-Tong Chen, Mohane Selvaraj Coumar,Wen-Hsin Lin, Zi-Jie Chen, John T.-A. Hsu, Yi-Hui Peng, Hui-Yi Shiaa, Wen-Hsing Lin, Chang-Ying Chua, Jian-Sung Wu, Chih-Tsung Lin, Ching-Ping Chen, Ching-Cheng Hsueh, Kai-Yen Chang, Li-Pin Kao, Chi-Ying F. Huang, Yu-Sheng Chao, Su-Ying Wu* (Corresponding author), Hsing-Pang Hsieh*, and Ya-Hui Chi* “Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules.” (2013) Proc Natl Acad Sci U S A. 110(19) :  E1779-87
  10. Jian-Sung Wu, Yi-Hui Peng, Jiun-Ming Wu, Chieh-Jui Hsieh, Szu-Huei Wu, Mohane Selvaraj Coumar, Jen-Shin Song, Jinq-Chyi Lee, Chi-Hui Tsai, Chiung-Tong Chen, Yu-Wei Liu, Yu-Sheng Chao, and Su-Ying Wu,* (Corresponding author) “Discovery of non-glycoside sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening” (2010) J. Med. Chem. 53(24),8770-8774.
  11. Yi-Hui Peng, Mohane Selvaraj Coumar, Jiun-Shyang Leou, Jian-Sung Wu, Hui-Yi Shiao, Chia-Hui Lin, Wen-Hsing Lin, Tzu Wen Lien, Xin Chen, John T.-A. Hsu, Yu-Sheng Chao, Ping-Chiang Lyu, Hsing-Pang Hsieh*and Su-Ying Wu,* (Corresponding author) “Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists” (2010) ChemMedChem  5 (10), 1707-1716
  12. Chun Hei Antonio Cheung, Su-Ying Wu, Tian-Ren Lee, Chi-Yen Chang, Jian-Sung Wu, Hsing-Pang Hsieh, Jang-Yang Chang* “Cancer Cells Acquire Mitotic Drug Resistance Properties Through Beta I-Tubulin Mutations and Alterations in the Expression of Beta-Tubulin Isotypes” (2010) Plos One 5(9): e12564
  13. Nien CY, Chen YC, Kuo CC, Hsieh HP, Chang CY, Wu JS, Wu SY, Liou JP, Chang JY. “5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors” (2010) J. Med. Chem. 53 (5), 2309-2313
  14. Coumar MS, Tsai MT, Chu CY, Uang BJ, Lin WH, Chang CY, Chang TY, Leou JS, Teng CH, Wu JS, Fang MY, Chen CH, Hsu JT, Wu SY, Chao YS, Hsieh HP. “Identification, SAR studies, and X-ray co-crystallographic analysis of a novel furanopyrimidine aurora kinase A inhibitor” (2010) ChemMedChem 5 (2), 255-267
  15. Wu YS, Coumar MS, Chang JY, Sun HY, Kuo FM, Kuo CC, Chen YJ, Chang CY, Hsiao CL, Liou JP, Chen CP, Yao HT, Chiang YK, Tan UK, Chen CT, Chu CY, Wu SY, Yeh TK, Lin CY, Hsieh HP. “Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.“ (2009) Med. Chem. 52 (15), 4941-4945
  16. Chiang YK, Kuo CC, Wu YS, Chen CT, Coumar MS, Wu JS, Hsieh HP, Chang CY, Jseng HY, Wu MH, Leou JS, Song JS, Chang JY, Lyu PC, Chao YS, Wu SY* (Corresponding author). “Generation of Ligand-Based Pharmacophore Model and Virtual Screening for Identification of Novel Tubulin Inhibitors with Potent Anticancer Activity “ (2009) Med. Chem. 52 (14), 4221-4233
  17. Chia-Hui Lin, Yi-Hui Peng, Mohane Selvaraj Coumar, Santhosh Kumar Chittimalla, Chun-Chen Liao, Ping-Chiang Lyn, Chin-Chieh Huang, Tzu-Wen Lien, Wen-Hsing Lin, John T.-A. Hsu, Jai-Hong Cheng, Xin Chen, Yu-Sheng Chao, Hwei-Jen Lee, Chiun-Gung Juo,Su-Ying Wu, *(Corresponding author),Hsing-Pang Hsieh,* “Design and structural analysis of novel pharmacophores for potent and selective PPARγ agonists “ (2009) Med. Chem. 52 (8), 2618-2622
  18. Mohane S Coumar, Jiun-Shyang Leou, Paritosh Shukla, Jian-Sung Wu, Ajay Dixit, Wen-Hsing Lin, Chung-Yu Chang, Tzu-Wen Lien, Uan-Kang Tan, Chun-Hwa Chen,  John Hsu, Yu-Sheng Chao, Su-Ying Wu,*(Corresponding author), Hsing-Pang Hsieh,* “Structure-based drug design of novel Aurora kinase A inhibitors: Structural basis for potency and specificity” (2009) Med. Chem. 52(4), 1050–10624.
  19. Gadarla Randheer Reddy, Ching-Chuan Kuo, Uan-Kang Tan, Mohane Selvaraj Coumar, Chi-Yen Chang, Yi-Kun Chiang, Mei-Jung Lai, Jiann-Yih Yeh, Su-Ying Wu, Jang-Yang Chang, Jing-Ping Liou , Hsing-Pang Hsieh “Synthesis and Structure−Activity Relationships of 2-Amino-1-aroylnaphthalene and 2-Hydroxy-1-aroylnaphthalenes as Potent Antitubulin Agents” (2008) Med. Chem. 51 (24), 8163-8167
  20. Mohane S Coumar, Jian-Sung Wu, Jiun-Shyang Leou, Chung-Yu Chang, Teng-Yuan Chang, Wen-Hsing Lin, John T Hsu, Yu-Sheng Chao, Su-Ying Wu,* (Corresponding author), Hsing-Pang Hsieh* “Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold” (2008) Med. Chem. Lett.18(5), 1623-1627
  21. I-Lin Lu, Keng-Chang Tsai, Yi-Kun Chiang, Weir-Torn Jiaang, Ssu-Hui Wu, Chia-Hui Chien, Shiow-Ju Lee, Xin Chen, Yu-Sheng Chao, and Su-Ying Wu,*(Corresponding author) “A Three-Dirnension Pharmacophore Model for Dipeptidy1 Peptidase IV Inhibitors” (2008) J. Med. Chem. 43(8), 1603-1611
  22. Neeraj Mahindroo, Yi-Huei Peng, Chia-Hui Lin, Uan-Kang Tan, Ekambaranellore Prakash, Tzu-Wen Lien,I-Lin Lu, Hong-Jen Lee, John Tsu-An Hsu, Xin Chen, Chun-Chen Liao, Ping-Chiang Lyu, Yu-Sheng Chao, Su-Ying Wu*(Corresponding author) and Hsing-Pang Hsieh* “Structural Basis for the Structure-Activity Relationships of Peroxisome Proliferator-Activated Receptor Agonists”  (2006) Med. Chem. 49 (21), 6421-6424
  23. I-Lin Lu, Neeraj Mahindroo, Po-Huang Liang, Yi-Hui Peng, Chih-Jung Kuo, Hsing-Pang Hsieh, Yu-Sheng Chao, and Su-Ying Wu*(Corresponding author) “Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of SARS-CoV Main Protease” (2006) Med. Chem. 49 (17), 5154-5161
  24. Keng-Chang Tsai, Shih-Yuan Chen, Po-Huang Liang, I-Lin Lu, Neeraj Mahindroo, Hsing-Pang Hsieh, Wei Lien ,Yu-Sheng Chao, Thy-Hou Lin* and Su-Ying Wu* (Corresponding author)”Discovery of a Novel Family of SARS-CoV Protease Inhibitors by Virtual Screening and 3D-QSAR Studies”(2006) Med. Chem. 49 (12), 3485-3495
  25. I-Lin Lu, Chien-Fu Huang, Yi-Hui Peng, Ying-Ting Lin,Hsing-Pang Hsieh,Chiung-Tong Chen, Tzu-Wen Lien, Hwei-Jen Lee, Neeraj Mahindroo, Ekambaranellore Prakash, Andrew Yueh, Chandra M. V. Goparaju ,Xin Chen, Chun-Chen Liao, Yu-Sheng Chao, John T.-A. Hsu*, and Su-Ying Wu* (Corresponding author) ”Structure-Based Drug Design of a Novel Family of PPARγ Partial Agonists: Virtual Screening, X-ray Crystallography and In Vitro/In Vivo Biological Activities”  (2006) Med. Chem.49 (9), 2703-2712
  26. Neeraj Mahindroo, Chiung-Chiu Wang, Chun-Chen Liao, Chien-Fu Huang, Tzu-Wen Lien, Yi-Huei Peng, I-Lin Lu, Wei-Jan Huang,Ying-Ting Lin, Ming-Chen Hsu, Chia-Hui Lin, Chia-Hua Tsai, Tsu-An Hsu, Xin Chen, Ping-Chiang Lyu, Yu-Sheng Chao, Su-Ying Wu* (Corresponding author),and Hsing-Pang Hsieh* ” Indol-1-yl Acetic Acids as Peroxisome Proliferator-Activated Receptor Agonists – Design, Synthesis, Structural Biology, and Molecular Docking Studies” (2006) Med. Chem. 49 (3), 1214-1216
  27. Hsu Tsu, Xin Chen, Chiung-Tong Chen, Shiow-Ju Lee, Chung-Nien Chang, Kuo-His Kao, Mohane Selvaraj Coumar, Yen-Ting Yeh, Chia-Hui Chien, Hsin-Sheng Wang, Ke-Ta Lin, Ying-Ying Chang, Ssu-Hui Wu, Yuan-Shou Chen, I-Lin Lu, Su-Ying Wu, Ting-Yueh Tsai, Wei-Cheng Chen, Hsing-Pang Hsieh, Yu-Sheng Chao, and Weir-Torn Jiaang“2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV “(2006) J. Med. Chem., 49 (1), 373 –380
  28. Neeraj Mahindroo, Chien-Fu Huang, Yi-Huei Peng, Chiung-Chiu Wang, Chun-Chen Liao, Tzu-Wen Lien, Santhosh Kumar Chittimalla, Wei-Jan Huang, Chia-Hua Chai, Ekambaranellore Prakash, Ching-Ping Chen, Tsu-An Hsu, Cheng-Hung Peng, I-Lin Lu, Ling-Hui Lee, Yi-Wei Chang, Wei-Cheng Chen, Yu-Chen Chou, Chiung-Tong Chen, Chandra M. V. Goparaju, Yuan-Shou Chen, Shih-Jung Lan, Ming-Chen Yu, Xin Chen, Yu-Sheng Chao, Su-Ying Wu* (Corresponding author), and Hsing-Pang Hsieh* ” Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.” (2005) J. Med. Chem., 48 (26), 8194 –8208
  29. I-Lin Lu, Shiow-Ju Lee, Hsu Tsu, Su-Ying Wu, Kuo-His Kao, Chia-Hui Chien, Ying-Ying Chang, Yuan-Shou Chen, Jai-Hong Cheng, Chung-Nien Chang, Tung-Wei Chen, Sheng-Ping Chang, Xin Che and Weir-Torn Jiaang “Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors “ (2005) Bioorg Med Chem Lett., 15 (13), 3271 –3275
  30. Hwei-Jen Lee, Young-Hsang Lai, Su-Ying Wu and Yu-Hou Chen “The effect of N-terminal truncation on double-dimer assembly of goose delta-crystallin “ (2005) Biochem J. 392,545-554
  31. George Kontopidis, Su-Ying Wu ,Daniella I. Zheleva, Paul Taylor , Campbell McInnes , David P. Lane, Peter M. Fischer and Malcolm D. Walkinshaw “Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design.”  (2005) PNAS .,102, 1871-1876
  32. Shudong Wang, Christopher Meades, Gavin Wood, Andrew Osnowski, Sian Anderson, Rhoda Yuill, Mark Thomas, Mokdad Mezna, Wayne Jackson, Carol Midgley, Gary Griffiths, Ian Fleming, Simon Green, Iain McNae, Su-Ying Wu, Campbell McInnes, Daniella Zheleva, Malcolm D. Walkinshaw, and Peter M. Fischer “2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity. “ (2004) Med. Chem., 47 (7), 1662-1675
  33. Su-Ying Wu, Iain McNae, George Kontopidis, Steven J. McClue, Campbell McInnes, Kevin J. Stewart, Shudong Wang, Daniella I. Zheleva, Howard Marriage, David P. Lane, Paul Taylor, Peter M. Fischer, and Malcolm D. Walkinshaw “Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop. “ (2003) , 11, 1-20
  34. Su-Ying Wu., Dornan, J., Kontopidis, G., Taylor, P., Walkinshaw., M-D. “The first direct determination of a ligand binding constant in protein crystals. “ (2001) Chem. Int. Ed., 40 (3),582-586
  35. Su-Ying Wu, Pérez,M.D., Puyol, P., Sawyer, L “b-Lactoglobulin binds palmitate within its central cavity.” Biological Chemistry “ (1999) J. Biological Chemistry., 274(1), 170-174

PATENT

  • US 2005/0222222 A1 R.O.C Patent pending 94107143 “Pyrrolidine compounds”
  • US 2006/0019967 A1 R.O.C Patent pending, 94136180 “SARS CoV Main Protease Inhibitors”

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