王文傑

王文傑  技術助研究員
生技與藥物研究所
藥物化學加值創新研發中心
Email: wcwang@nhri.edu.tw

 

EDUCATION

  • Ph.D., Department of Chemistry, Fu Jen Catholic University, Taiwan
  • B.S., Department of Chemistry, Fu Jen Catholic University, Taiwan

PROFESSIONAL EXPERIENCES

  • Assistant Investigator, Value-Added MedChem Innovation Center (VMIC), Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes (2011-present)
  • Postdoctoral Fellow, Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes (2005-2010)

EXPERTISE/RESEARCH INTERESTS

  • Synthetic Organic Chemistry
  • Medicinal Chemistry
  • High throughput parallel synthesis
  • Structure and knowledge-based drug design
  • Metabolism-guided drug design
  • Development of novel synthetic platform
  • Anticancer drug discovery – kinase as mainly drug target

PUBLICATIONS

  1. Chang Hsu, Y.; Coumar, M. S.; Wang, W. C.; Shiao, H. Y.; Ke, Y. Y.; Lin, W. H.; Kuo, C. C.; Chang, C. W.; Kuo, F. M.; Chen, P. Y.; Wang, S. Y.; Li, A. S.; Chen, C. H.; Kuo, P. C.; Chen, C. P.; Wu, M. H.; Huang, C. L. Yen, K. J.; Chang, Y. I.; Hsu, J. T.; Chen, C. T.; Yeh, T. K.; Song, J. S.; Shih, C.; Hsieh, H. P.* “Discovery of BPR1K871 – a quinazoline based multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation” Oncotarget, 2016, 7, 86239-86256.
  2. Chang, C. F.; Lin, W. H.; Ke, Y. Y.; Lin, Y. S.; Wang, W. C.; Chen, C. H.; Kuo, P. C.; Hsu J. T.; Uang, B. J. *; Hsieh, H. P. * “Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design” Eur. J. Med. Chem. 2016, 124, 186-199.
  3. Ke, Y. Y.; Singh, V. K.; Coumar, M. S.; Chang Hsu, Y.; Wang, W. C.; Song, J. S.; Chen, C. H.; Lin, W. H.; Wu, S. H.; Hsu, J. T.; Shih, C.; Hsieh H. P.* “Homology Modeling of DFG-in FMS-like Tyrosine Kinase 3 (FLT3) and Structure-based Virtual Screening for Inhibitor Identification” Sci. Rep. 2015, 5, 11702.
  4. Lee, G. A.; * Lee, H. Y.; Wang, W. C.; Cherng, C. H. “Auto de-bromine-coupling reactions of 1-aryl-7-bromocycloheptenes” Tetrahedron, 2014, 70, 2956-2961.
  5. Lee, C. C.; Shiao, H. Y.; Wang, W. C.; Hsieh, H. P.* “Small-molecule EGFR Tyrosine Kinase Inhibitors for the Treatment of Cancer” Expert. Opin. Investig. Drugs. 2014, 23, 1333-1348.
  6. Wang, W.C.; Shiao, H. Y.; Lee, C. C.; Fung, K. S.; Hsieh, H. P.* “Anaplastic Lymphoma Kinase (ALK) Inhibitors: A Review of Design and Discovery” MedChemComm. 2014, 5, 1266-1279.
  7. Ke, Y. Y.; Coumar, M. S.; Shiao, H. Y.; Wang, W. C.; Chen, C. W.; Song, J. S.; Chen, C. H.; Lin, W. H.; Wu, S. H.; Hsu, J. T.; Chang, C. M.; Hsieh, H. P.* “Ligand Efficiency Based Approach for Efficient Virtual Screening of Compound Libraries” Eur. J. Med. Chem. 2014, 83, 226-235.
  8. Ke, Y. Y.; Shiao, H. Y.; Chang Hsu, Y.; Chu, C. Y.; Wang, W. C.; Lee, Y. C.; Lin, W. H.; Chen, C. H.; Hsu, J. T.; Chang, C. W.; Lin, C. W.; Yeh, T. K.; Chao, Y. S.; Coumar, M. S.*; Hsieh, H. P.* “3D-QSAR-Assisted Drug Design: Identification of a Potent Quinazoline-Based Aurora Kinase Inhibitor” ChemMedChem. 2013, 8, 136-148.
  9. Lee, G. A.*; Wang, W. C.; Shieh, M.; Kuo, T.S. “A Novel Synthesis of Calix[4]thiophenes and Calix[4]furans” Chem. Commun. 2010, 46, 5009-5011.
  10. Lee, G. A.*; Tsai, R. T.; Wang, W. C.; Liu, Y. T. “The Synthesis and Trapping of        1-Naphthylcyclopropenes” J. Chin. Chem. Soc. 2010, 57, 800-804.
  11. Lee, G. A.*; Wang, W. C.; Jiang, S. F.; Chang, C. Y.; Tsai, R. T. “The Crossed [2+2] Cycloaddition of 1-Phenylcyclopropene and 1-Bromo-2-phenylcyclopropene” J. Org. Chem. 2009, 74, 7994-7997.
  12. Chen, K. C.; Wang, W. C.; Chen M. Y.; Chen W. C.; Her, M. C.; Lee G. A.* “Regio- and Stereoselectivity of Ene Reactions: The Dimerization of 1,3-Fused Bicyclic 2-Trimethylsilylcyclopropenes” Eur. J. Org. Chem. 2007, 953-958.

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